PamperMySkin articles on Revaleskin and other anti-aging skincare products.
 
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SkinCare Articles regarding antioxidant CoffeeBerry and other all natural skin cream additives.

Skin Care tips for Diabetics | What Causes wrinkles and how to fight them.

Volume 38, Issue 4, Page 1 (April 2007) by BRUCE JANCIN (Denver Bureau)

Novel Antioxidant Shows Promise as Photoaging Topical: Data encouraging for coffee-berry extract.

MAUI, HAWAII — A novel skin product whose active ingredient is an extract of unripe coffee berries has shown preliminary evidence of clinical efficacy for treatment of photoaging, Dr. Joel L. Cohen said at the annual Hawaii Dermatology Seminar sponsored by Skin Disease Education Foundation. The nonprescription three-step topical therapy is being launched into the marketplace this spring by Stiefel Laboratories under the trade name RevaleSkin. It consists of a 1.0% coffee-berry day cream, a 1.0% night cream, and a 0.1% facial cleanser. The company describes it as more than a cosmeceutical or nutriceutical, but as something new: an organiceutical backed by scientific data.

In addition to the evidence of safety and efficacy provided by the randomized double-blind trials, further support comes from positive pathologic and in vitro studies showing enhanced collagen production by fibroblasts. Moreover, there is a biologically plausible mechanism of action based upon coffee berry extract's uniquely potent antioxidant effects, added Dr. Cohen, an Englewood, Colo., dermatologist and president of the Colorado Dermatologic Society.

The coffee berry—that is, the fruit of the coffee plant, including bean, hull, and pulp—is at least 15-fold richer in antioxidants than are green tea, fruits, or vegetables by the Oxygen Radical Absorbance Capacity assay developed by the Department of Agriculture. The polyphenol antioxidants in which it is exceptionally rich are chlorogenic acid, quinic acid, ferulic acid, and condensed proanthocyanidins.

Dr. Cohen presented a 6-week double-blind clinical trial involving 30 women with moderate photoaging, none of whom were permitted to use any topical products except those provided for the study. Twenty applied the coffee berry products full-face. The other 10 used them on one side of the face and the vehicle on the other. The regimen consisted of once-daily use of the day and night creams and twice-daily application of the cleanser.

Blinded expert grading at 6 weeks in the split-face cohort showed a mean 30% global improvement on the coffee berry-treated side and 7% improvement on the control side. A 25% improvement in fine lines and wrinkles was seen on the active-treatment side, compared with less than 3% on the opposite side. The 15% improvement in photoaging-induced pigmentary changes was threefold greater than on control skin. There were no significant differences in skin roughness and dryness. In the 20 patients treated full-face, the blinded evaluators scored standardized photographs as 30% improved over baseline both globally and in pigmentary changes, 20% improved in fine lines and wrinkles, and 15% improved in roughness and dryness.

Biopsies and polymerase chain reaction studies at 6 weeks showed significantly less fibroblast matrix metalloproteinase-1 and collagenase activity and increased collagen production, compared with baseline. Side effects were limited to mild Dr Cohen is a spokesperson for Steifel Labs and Revaleskinshort-term redness and burning. Dr. Cohen also provided the interim 6-week results of an ongoing 12-week randomized double-blind clinical trial led by Dr. Zoe Draelos of Wake Forest University, Winston-Salem, N.C. In that study, 50 women with moderate photoaging were assigned to use the coffee-berry products or Johnson & Johnson's Purpose skin moisturizing products as a control.

At 6 weeks, patients in the coffee-berry arm showed significantly less transepidermal water loss and erythema than did controls. The coffee-berry group also displayed significantly less skin roughness/dryness and more skin hydration, compared with baseline. How does Dr. Cohen see coffee berry extract fitting into clinical practice? By far the single most important measure patients can take to protect against photoaging, he stressed, is scrupulous use of sunscreens. The next tier is topical retinoid therapy. “Retinoids are clearly the mainstay of our armamentarium and will continue to be so for some time in terms of treating photodamage. We've got 2 decades of data on the effects of the retinoids. But for patients who want to use something extra in terms of antioxidants and natural components, coffee-berry extract appears to be very promising,” he said.

For patients who want to use something extra, coffee-berry extract appears to be promising. DR. COHEN

Dr. Cohen is on the speakers' bureau for and a consultant to Stiefel.

www.Prevention.com reprint shown below for their CoffeeBerry article.

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Self Magazine Cover and Article praising RevaleSkin's CofeeBerry skin restoration properties....

Botanical Products Move to Front of Cosmeceuticals Class
SkinandAllergynews.com article.... Volume 39, Issue 2, Page 33 (February 2008)

LAS VEGAS — Botanicals have become the new hot commodity in cosmeceuticals, as part of a larger trend that hasSkinandAllergyNews.com articles on Revaleskin and coffeeberry antioxidant capabilities in skincare. consumers searching for natural ingredients in all kinds of products. “Natural ingredients have become popular again,” Dr. Diane Berson said at the annual meeting of the American Society of Cosmetic Dermatology and Aesthetic Surgery. “They have always been popular, but they definitely are having a renaissance.”

“Part of this is consumer driven. Patients want things that are natural, so they want botanicals,” she added. It is estimated that 40%–50% of new skin care products include a botanical agent, said Dr. Berson, who is with the department of dermatology at Cornell University, New York.

** Coffeeberry. The extract of the husk around the coffee cherry contains quite powerful antioxidants. According to Stiefel Laboratories Inc., the company that makes the product (Revaléskin), its antioxidants have a free radical-absorbing capacity that is 10 times greater than those in green tea.

In a trial of 10 women treated in a split-face fashion for 6 weeks, the coffeeberry extract produced a 30% global improvement on the treated sides, versus 7% improvement on the control sides (“Novel Antioxidant Shows Promise as Photoaging Topical,” April 2007, p. 1). The problem is that the study involved only 10 patients, Dr. Berson noted.... Even so, “I think we are going to be hearing more about this extract,” she said.

Revaleskin with antioxidant CoffeeBerry plays the major role in revolutionizing the skincare industry. View why the media and face skin experts are talking about the results from using the world's strongest natural anti-oxidant in a skin cream. You can now purchase Revaleskin right here!

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Volume 38, Issue 5, Page 25 (May 2007) by Dr. LESLIE S. BAUMANN, M.D. director of cosmetic dermatology at the University of Miami

ARTICLE: Coffea arabica and CoffeeBerry Extract

The coffee plant Coffea arabica is cultivated worldwide and is, of course, a source of the wildly popular beverage. In spite of its name, C. arabica actually comes from Ethiopia and is thought to haveScience puts together the pieces of the puzzle for great skin care products been introduced into Arabia before the 1400s, Java before 1700, and the West Indies and Central and South America in the 1700s (Morton, J.F. “Major Medicinal Plants.” Springfield, Ill.: Thomas, 1977).

Extracts of the coffee plant have been shown to exhibit antioxidant activity. Two recent studies, for example, point to the antioxidant properties of roasted C. arabica. In one, researchers prepared coffee model systems from combinations of compounds, including chlorogenic acid, sucrose, and cellulose. Tests revealed that antioxidant activity exhibited a positive, nonlinear relationship with the level of chlorogenic acid, a known antioxidant, after roasting (J. Agric. Food Chem. 2002;50:3751–6).

In the other study, C. arabica and C. robusta (C. canephora) revealed potent activity against the hydroxyl radical in an in vitro assay, and ex vivo in IMR32 cells. The investigators concluded that both green and roasted coffee exhibit antiradical activity, with 5-O-caffeoylquinic acid as the most active constituent, and that the roasting process stimulates high-molecular-weight components to display antiradical activity in coffee. The authors speculated that these findings could account for the neuroprotective effects associated with coffee consumption in recent epidemiologic studies (J. Agric. Food Chem. 2004;52:1700–4). In fact, three recent epidemiologic studies have provided evidence linking regular coffee and caffeine consumption with a lower incidence or reduced risk of developing Parkinson's disease (J. Neurosci. 2001;21:1–6; Ann. Neurol. 2001;50:56–63; JAMA 2000;283:2674–9).

Coffee Berry Discovery:

Although much attention has been focused on coffee beans, particularly roasted beans, the fruit of the coffee plant has long been ignored because it decays rapidly....

Coffee berry, the fruit that grows on C. arabica, is suffused with polyphenols, especially chlorogenic acid, condensed proanthocyanidins, quinic acid, and ferulic acid. Coffee berry is believed to exhibit higher antioxidant activity than do green tea, white tea, pomegranates, blueberries, strawberries, and raspberries. Polyphenols, which are secondary metabolites in plants, play an integral role in a healthful diet and are key constituents of fruits, vegetables, grains, coffee beans, and green and black tea (Annu. Rev. Nutr. 2002;22:19–34; Nutr. Cancer 1993;20:21–9; Pharmacol. Ther. 2001;90:157–77; Am. J. Med. 2002;113 (suppl. 2):71–88; Pol. J. Pharmacol. 1996;48:555–64; J. Sci. Food Agric. 1999;79:362–72; Free Radic. Biol. Med. 2001;30:1213–22; Biomed. Papers 2003;147:137–45).

Copious research during the past several years has shown that polyphenols represent a wealth of potential health benefits, typically related to anti-inflammatory and antioxidantThe 3 product kit of Revaleskin features the power of CoffeeBerry natural anti-oxidents. properties. Consequently, pharmaceutical and cosmeceutical manufacturers have targeted the activity of polyphenols for medical and cosmetic applications. A method of translating the claimed prodigious properties of the coffee-berry fruit has reportedly been developed. In fact, the extract of the fruit was acknowledged as a suitable ingredient for dermatologic application at the February 2007 meeting of the American Academy of Dermatology.

RevaléSkin was the first skin care product line based on the purported antioxidant capacity of coffee-berry polyphenols. Stiefel Laboratories, the manufacturer, claims that this line of products is indicated for antiaging treatment. Specifically, the product line is said to confer antioxidant activity and protection against UVA and UVB radiation (SKIN & ALLERGY NEWS, April 2007, p. 1).

The primary active ingredient in these products is CoffeeBerry extract (a registered trademark of VDF FutureCeuticals). In proprietary research, CoffeeBerry extract exhibited 10 times as much antioxidant capacity as green tea did in the oxygen radical absorbance capacity assay. In addition, Stiefel claims that a test of the RevaléSkin formulation over a 6-week period resulted in improvement in hyperpigmentation, fine lines and wrinkles, and overall appearance. According to Stiefel, there were no reports of irritation by patients with sensitive skin. The products in the RevaléSkin line (a cleanser, day cream, and night cream), which contain 1% CoffeeBerry extract, have been available to patients through medical aesthetic professionals since spring 2007. Before CoffeeBerry extract was used in RevaléSkin products, it had been employed in dietary supplements and food products.

Sövage Instant Lip Plumper, a new serum manufactured by Sövage Dermatologic Laboratories, is another product that contains C. arabica as an active ingredient, although CoffeeBerry extract is not included. According to the manufacturer, this formulation hydrates and protects the lips, and can alter the appearance of lip contour, size, and color. The C. arabica plant is also used in some botanical formulations intended to treat cellulite. The caffeine in these other products is extracted from the leaves rather than the berries (Dermatol. Surg. 2005;31:866–72). Topical products that contain C. arabica—and CoffeeBerry extract in particular—are generally regarded as safe for all skin types.

Conclusions by Dr. LESLIE S. BAUMANN, M.D

Given the widespread use of the C. arabica plant, and growing scientific interest in exploring and expanding its use, it would certainly be convenient and cost effective if companies that harvested the plant also used its fruit in some capacity. Preliminary evidence suggests that coffee berry warrants consideration for its strong antioxidant potential. However, claims that it improves wrinkles likely stem from a moisturizing effect, as we all know now that antioxidants prevent wrinkles but do not treat wrinkles. The therapeutic effects seen on hyperpigmentation make sense because antioxidants play a role in the pigmentation process.





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